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NSAIDs and corticosteroids have a short onset of action while DMARDs can take several weeks or months to demonstrate a clinical effect. The best available evidence shows that DMARDs offer no benefit to treating pain, and it would be unethical to use them on people with significant chronic pain or in patients with other medical conditions. There are limitations to this study that warrant review. First, as in most observational cohorts, there was considerable heterogeneity in the effects of DMARDs and corticosteroids. Among those patients who responded to DMARDs and corticosteroids, most responders had a history of pain, and there was a very limited number of responders who had a history of fibromyalgia or chronic low back pain. In addition, we did not have a baseline measure of pain, which might have improved the results. Second, we measured the efficacy of either DMARD or corticosteroid medication with a relatively large number of patients, possibly resulting in an underestimate of the absolute response to DMARDs and corticosteroids. Third, the response to DMARDs and corticosteroids was assessed by assessing the number of patients in the randomized groups that received more than one DMARD or corticosteroid, and the number of patients that received more than one of both DMARD or corticosteroid. These factors may have influenced the number of patients receiving treatment. For a given DMARD and corticosteroid dose, a number of patients received the highest dose, so that response to both high doses would have been greater than placebo and higher than the lowest dose and the lowest dose combined. There may also have been some differential treatment among the patients receiving the same treatment. In conclusion, we found no significant benefit and some increased risk for adverse events among patients who received DMARDs and corticosteroids compared to placebo. Our study needs to be replicated, but the data should not be considered definitive until they are repeated with larger numbers of patients. Acknowledgments. We thank Michael T. Tappin, PhD, and David R. Kocher, PhD, for their contributions to the design and execution of the study. This work was supported in part by National Institutes of Health grants UL1 RR02495 and ACI 111072. The funders had no role in study design; data collection and analysis; writing of the manuscript; or decision to submit for publication. Similar articles:
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